Hemorrhagic venous infarction from thrombosis of vein of Labbe
How to cite this article: Waack AL, Ranabothu M, Vattipally VR. Hemorrhagic venous infarction from thrombosis of vein of Labbe. J Neurosci Rural Pract 2023;14:382-3.
A 39-year-old woman presented with complaints of a progressive headache over the preceding several days. No specific neurological deficits were apparent, although the patient did report that she was currently taking oral contraceptives. The patient underwent emergent computed tomography (CT) imaging, which demonstrated venosinus thrombosis with associated cortical infarction [Figure 1a-e]. The patient was treated with anticoagulation therapy and mechanical thrombolysis.
The superficial and deep venous systems of the brain drain into the larger dural venous sinuses, and venous thrombosis may develop at any location within this venous system. Increased retrograde pressure from venosinus occlusion can result in vasogenic edema, cytotoxic edema/ischemia, and possibly intracranial hemorrhage. Patients often present non-specific symptoms with variable onset, making diagnostic imaging imperative for diagnosis. Non-enhanced CT (NECT) is the initial imaging modality, followed by contrast-enhanced CT (CT C+) cerebral venography. NECT allows for direct thrombus visualization, in which the thrombus presents as a hyperattenuating lesion. On CT C+ imaging, the dural sinus, but not the thrombus, is hyperattenuated.[1,2] The characteristic “empty delta sign” may be demonstrated if the thrombus is located in the superior sagittal sinus or the transverse sinus. Non-specific indirect signs, such as ischemia or hemorrhagic infarction, may be suggestive of thrombosis as well.[1,2] MRI imaging may be confounded by paramagnetic properties of thrombus; although, a lack of T1/T2 flow voids can be suggestive of cerebral venous thrombosis (CVT).[1,2] CVT is initially treated w/anticoagulation therapy; if unsuccessful, follow-up with mechanical thrombolysis.
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