Cerebral venous thrombosis in ulcerative colitis

Address for correspondence: Dr. Bindu Menon Department of Neurology, Narayana Medical College and Superspeciality Hospital Chintareddypalem, Nellore, Andra Pradesh India bneuro_5@rediffmail.com

Journal of Neurosciences in Rural Practice

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Abstract

ABSTRACT

Ulcerative colitis has been reported to show hyper coagulation leading to peripheral and rarely central thrombosis. A 35‑year‑old female was admitted with chief complaints of increased frequency of bloody diarrhea, abdominal pain, and weight loss for 2 months. The patient was diagnosed to have ulcerative colitis after sigmoidoscopy and biopsy and she was started on treatment. Two days later, the patient developed headache and seizures. Magnetic resonance imaging of brain showed cerebral venous thrombosis with venous infarcts. A high index of clinical suspicion is needed to diagnose this uncommon condition so that appropriate treatment can be initiated.

Keywords

Cerebral venous thrombosis

irritable bowel syndrome

ulcerative colitis

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Conflicts of interest

None declared

REFERENCES

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[1] Talbot R. W., Heppell J, Dozois R. R., Beart R. W., . Vascular complications of inflammatory bowel disease. Mayo Clin Proc. 1986;61:140-5.
[Google Scholar]

[2] Ozdil S, Akyuz F, Pinarbasi B, Demir K, Karaca C, Boztas G, et al. . Ulcerative colitis: Analyses of 116 cases (do extraintestinal manifestations effect the time to catch remission?) Hepatogastroenterology. 2004;51:768-70.
[Google Scholar]

[3] Twig G, Zandman-Goddard G, Szyper-Kravitz M, Shoenfeld Y, . Systemic thromboembolism in inflammatory bowel disease: Mechanisms and clinical applications. Ann N Y Acad Sci. 2005;1051:166-73.
[Google Scholar]

[4] Umit H, Asil T, Celik Y, Tezel A, Dokmeci G, Tuncbilek N, et al. . Cerebral sinus thrombosis in patients with inflammatory bowel disease: A case report. World J Gastroenterol. 2005;11:5404-7.
[Google Scholar]

[5] Danese S, Papa A, Saibeni S, Repici A, Malesci A, Vecchi M, . Inflammation and coagulation in inflammatory bowel disease: The clot thickens. Am J Gastroenterol. 2007;102:174-86.
[Google Scholar]

[6] Ameri A, Bousser M. G., . Cerebral venous thrombosis. Neurol Clin. 1992;10:87-111.
[Google Scholar]

[7] Ferro J. M., Canhão P, Bousser M. G., Stam J, . Barinagarrementeria F; ISCVT Investigators Early seizures in cerebral vein and dural sinus thrombosis: Risk factors and role of antiepileptics. Stroke. 2008;39:1152-8.
[Google Scholar]

[8] Guenther G, Arauz A, . Cerebral venous thrombosis: A diagnostic and treatment update. Neurologia. 2011;26:488-98.
[Google Scholar]

[9] Coutinho J. M., Ferro J. M., Canhão P, Barinagarrementeria F, Bousser M. G., Stam J, . ISCVT Investigators Unfractionated or low-molecular weight heparin for the treatment of cerebral venous thrombosis. Stroke. 2010;41:2575-80.
[Google Scholar]