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Letters to the Editor
5 (
1
); 94-94
doi:
10.4103/0976-3147.127935

Use of triptans for the control of headache in bacterial meningitis

Wiwanitkit House, Bangkhae, Bangkok, Thailand
Address for correspondence: Prof. Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok, Thailand. E-mail: wviroj@yahoo.com
Licence

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Disclaimer:
This article was originally published by Medknow Publications & Media Pvt Ltd and was migrated to Scientific Scholar after the change of Publisher.

Sir,

The use of triptans for the control of headache in bacterial meningitis is an interesting topic for discussion.[1] Based on theoretical concern,[2] the feasibility can be seen. Nevertheless, as Mojumder proposed, there are several issues for consideration regarding the effectiveness and safety of triptans. Whether the “thrombogenic environment” has any interrelationship with triptans is an important thing to be further studied. Based on our best knowledge, zolmitriptan and naratriptan have no effect on platelet or coagulation factor. This might assume that using triptans is safe. However, there is a report showing a possibility of increased intrapartum blood loss, which implies anti-thrombogenic phenomenon in the pregnant woman who received triptans.[3] If the anti-thrombogenic property actually exists, it might be a good counter factor to the thrombogenic environment in meningitis. Further studies on this topic are recommended.

References

  1. , . Careful consideration for use of triptans for the control of headache in bacterial meningitis. J Neurosci Rural Pract. 2014;5:93-4.
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  2. , . Nitrite, vasodilation, and headache in bacterial meningitis: Theoretical approach. J Neurosci Rural Pract. 2013;4:374-5.
    [Google Scholar]
  3. , , , . Triptan exposure during pregnancy and the risk of major congenital malformations and adverse pregnancy outcomes: Results from the Norwegian mother and child cohort study. Headache. 2010;50:563-75.
    [Google Scholar]

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