Unilateral variant motor innervations of flexure muscles of arm

Introduction

As per the medical and surgical aspects, the nerve supply of arm is very important. The musculocutaneous nerve (MCN) branches out from the lateral cord of brachial plexus. It passes through the Corcobrachialis muscle to innervate it and the biceps brachii muscle. Then it passes between the biceps brachii and brachialis muscle, gives a branch to supply later and continues as the lateral cutaneous nerve of forearm without exhibiting any communication with the median nerve (MN) or any other nerve. The MN passes through the anterior compartment of arm without innervating any flexure muscle of arm.[1]

Variations in the formation and branching pattern of the brachial plexus and the nerves supplying upper limb are common and have been reported continuously since the 19^th century.[2] The anatomical variations of peripheral nerves are important to orthopedic surgeons, neurophysicians, physiotherapist and radiologists. Such comprehension is useful in nerve grafting, neurophysiological evaluation for diagnosing peripheral neuropathies.[3] The present variation was observed during routine dissection at the Anatomy department of Medical College of rural hospital.

Case Report

In a 58-year-old male cadaver, the unilateral variation in motor innervations of the left arm is reported. The pectoralis major and pectoralis minor muscles were removed to expose the brachial plexus. Skin, superficial and deep fascia, was excised to get a view of the arm contents. The musculocutaneous nerve was found to be absent. A branch of the MN was found to be supplying the coracobrachialis muscle. This branch of MN, arising from its lateral side, entered the substance of the coracobrachialis muscle [Figure 1]. In the middle of the arm, the MN was found to be giving the second branch from its lateral side. This branch of MN bifurcated and supplied the long and short head of biceps brachii muscle separately [Figure 2]. The MN was found to be giving a third branch in the arm, running downward and laterally in between the biceps brachii and brachialis muscle. This third branch was supplied the brachialis muscle and continued as the lateral cutaneous nerve of forearm. Dissection was continued to expose the entire brachial plexus from the origin and it was found to be normal. The right sided structures were found to be normal.

Close

Figure 1

Dissection of the axilla and anterior compartment of arm showing the variation of Median nerve. (BA: Brachial artery; Br: Brachialis muscle; CBr: Coracobrachialis muscle; DL: Deltoid; LHBB: Long head of Biceps brachii muscle; MN: Median nerve; SHBB: Short head of Biceps brachii muscle; 1: Branch to coracobrachialis; 2: Branch to Biceps brachii; 3: Third branch of median nerve; 4: Branch to brachialis; 5: Lateral cutaneous nerve of forearm).

Export to PPT

Close

Figure 2

Closure view showing nerve supply of biceps brachii and brachialis muscles. (BA: Brachial artery; Br: Brachialis muscle; LhBB: Long head of Biceps brachii muscle; MN: Median nerve; ShBB: Short head of Biceps brachii muscle; 1: Branch to Biceps brachii; 2: Branch to Short head of Biceps brachii; 3: Branch to Long head of Biceps brachii; 4: Branch to brachialis; 5: Lateral cutaneous nerve of forearm)

Export to PPT

Discussion

In this case report, the motor branches of flexure muscles of the left arm were found to be arising from the MN. The MN branch supplying the brachialis muscle was found to be continuing as the lateral cutaneous nerve. Thus, the MCN was replaced by the MN branches. The origin of brachial plexus was found to be normal. Variants of the branching pattern of MCN and MN have been well described by many authors.[45] Le Minor (1992) classified these variations into five types:[6]

Type 1: No communication between MN and MCN.

Type 2: The fibers of the medial root of the MN pass through the MCN and join the MN in the middle of the arm.

Type 3: The fibers of the lateral root of the MN pass through the MCN and after some distance leave it to form the lateral root of the MN.

Type 4: The MCN fibers join the lateral root of the MN and after some distance the MCN arise from the MN.

Type 5: The MCN is absent and all the MCN fibers pass through lateral root of MN; fibers to the muscles supplied by MCN branch out directly from MN. In this type, the MCN does not pierce the coracobrachialis muscle.

Present findings indicate the presence of Le Minor Type V variant. Surgeons should keep such possible variations of the MCN and the MN surgeon in mind during constructive shoulder arthroplasty and treating shoulder dislocations.

The existence of this variation described in our case report may be attributed to the random factors influencing the mechanism of formation of the limb muscles and the peripheral nerves during the embryonic life. In the context that ontogeny recapitulates phylogeny; it is possible that the variation seen in the current study is the result of developmental anomaly. In the human being, the forelimb muscles develop from the mesenchyme of paraxial mesoderm in the fifth week of the intrauterine life.[7] The regional expression of five Hox D (Hox D 1 to Hox D 5) genes is responsible for upper limb development.[8] The motor axons arrive at the base of the limb bud; they mix to form the brachial plexus in the upper limb. The growth cones of the axons continue in the limb bud.[7] The guidance of the developing axons is regulated by the expression of chemo-attractants and chemo-repulsant in highly coordinated sight specific fission. Tropic substances attract the correct growth cones or support the viability of the growth cones that happen to take the right path. Tropic substances include the brain-derived neurotropic growth factor, c-kit ligand, neutrin-1, neutrin-2 etc.[9] The significant variations in nerve pattern may be the result of altered signaling between the mesenchymal cells and the neuronal growth cones or circulatory factors at the time of fission of brachial plexus cords.