Seizure Outcome in Adult Patients with Supratentorial Cavernomas

Rahsan Kemerdere; Orkhan Alizada; Tugce Ayman; Oguz Baran; Seher Naz Yeni; Taner Tanriverdi

doi:10.1055/s-0040-1721205

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Original Article

12 (

); 267-272

doi:

10.1055/s-0040-1721205

Seizure Outcome in Adult Patients with Supratentorial Cavernomas

Rahsan Kemerdere¹, Orkhan Alizada¹, Tugce Ayman¹, Oguz Baran^2,, Seher Naz Yeni³, Taner Tanriverdi¹

1 Department of Neurosurgery, Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey

2 Department of Neurosurgery, Koç University Hospital, Istanbul, Turkey

3 Department of Neurology, Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey

Oguz Baran, MD, PhD Department of Neurosurgery, Koç University Hospital Istanbul Turkey oguzbaran@gmail.com

Epub ahead of print: 2020-11-12, Published: 2021-04-23

Journal of Neurosciences in Rural Practice

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This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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This article was originally published by Thieme Medical and Scientific Publishers Pvt. Ltd. and was migrated to Scientific Scholar after the change of Publisher.

Abstract

Background Cavernomas are usually found in the supratentorial area, and epileptic seizures are one of the presenting symptoms.

Objective This study aims to provide the seizure outcome in adult patients who underwent surgical excision of single supratentorial cavernomas.

Materials and Methods A total of 23 patients with single supratentorial cavernomas were operated between May 2011 and January 2019. Pre- and postoperative seizure semiology, clinical, and radiological findings were collected from medical records. At the last follow-up, each patient was seen during regular visits and clinical variables were noted.

Results The mean age was 37.08 ± 10.5 years, and 11 (57.8%) and 12 (52.2%) were females and males, respectively. Headache (43.5%) and seizure (43.5%) were the most common presenting symptoms. Cavernomas were located on the right side in 13 and on the left side in 10 patients. The most common locations were the frontal (43.5%) and temporal (43.5%) lobes. The mean follow-up in this series was 41.4 ± 30.8 months. Our results showed that surgery was effective in seizure outcome, as almost 70% of patients who had seizure before surgery was seizure free after surgery, and the difference between those who had seizure pre- and postoperative periods was statistically significant (p = 0.0001).

Conclusion Surgery is safe and effective for supratentorial cavernomas. The excision of cavernoma together with the surrounding hemosiderin should be performed to obtain a satisfactory seizure outcome.

Keywords

cavernoma

cavernous angioma

cavernous hemangioma

epilepsy

seizure

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Introduction

Cavernomas, also known as cavernous hemangiomas or cavernous angiomas, account for approximately 10 to 15% of all vascular lesions of adult brain.1 Cavernomas are composed of enlarged, sinusoidal, and thin-walled blood vessels without intervening neural tissues, and they are angiographically occult lesions. The majority is found in the supratentorial area, and epileptic seizures are one of the presenting symptoms, manifesting at a rate of 70%.2 Diagnosis has become easier after the introduction of advanced magnetic resonance imaging (MRI) into the field. The importance of epileptic seizures in patients with supratentorial cavernomas is that almost 40% becomes medically refractory.3 Headaches and hemorrhage are also common, and the risk of hemorrhage is estimated at 3% per person per year.1 3 4

Several studies documented the clinical and radiological features of cavernomas, but there is still a controversy whether they should be treated conservatively with antiepileptic drugs (AED) with respect to seizures or whether resective surgery is mandatory.1 3 4 The available data in the current literature show that there is no doubt that surgery should be performed on symptomatic cavernomas to prevent future bleeding and refractory seizure.5 6 7 8 9 Many previous studies reported relatively good surgical and seizure outcomes and emphasized the importance of early surgery.5 6 7 8 9 Another controversy that is still ongoing is the extent of excision. As far as we know, there are three main types of surgical excisions for cavernomas: excision of the lesion only (excision of cavernomas without the surrounding hemosiderin), lesionectomy (excision of cavernomas together with the surrounding hemosiderin), and extended lesionectomy (excision of 1 or 2 cm beyond the cavernomas and the surrounding hemosiderin). Comparative studies have demonstrated that lesionectomy is superior to the excision of lesions only in patients with seizure, and lesionectomy is sufficient to obtain a favorable seizure outcome.5 8 Extended lesionectomy has been suggested to patients who show medically intractable epilepsy, and whose preoperative diagnostic work-up such as electroencephalography (EEG) has proved that the epileptic zone is more extensive than the cavernoma and the surrounding hemosiderin.5 7 The most challenging part of surgery is encountered when a cavernoma is located in or close to the eloquent area. In these situations, awake craniotomy with cortical electric stimulation seems to be rational.

This study, which includes a retrospective cohort of adult patients who underwent surgery on supratentorial cavernomas, aims to share our experience in surgical (and seizure) outcome with the readers. All surgeries were performed by the same surgeon with the same surgical technique (lesionectomy: excision of the cavernoma together with the surrounding hemosiderin rim).

Materials and Methods

Patients

This retrospective study was approved by the local ethics committee and does not include any data disclosing the patients’ identity. Between May 2011 and January 2019, a total of 31 patients underwent cavernoma surgery. Six patients who were lost to follow-up, one patient with cerebellar cavernoma, and one with multiple supratentorial cavernomas were excluded from the data. Ultimately, 23 patients with single supratentorial cavernomas were included and analyzed in this study.

Methods

Data included pre- and postoperative variables: age at surgery, sex, presenting symptom, presence of seizure, type and frequency of seizure, findings from neurologic examinations, MRI features (site, side, and presence of hemosiderin rim), number of AED used, findings from EEG if obtained, and surgical complications if present. Seizure frequency was divided into two groups those who had only one seizure and those who experienced more than one seizure until surgery. All patients had pre- and postoperative head MRI with all sequences assessed by our experienced neuroradiologists. Seizure outcome was divided into two groups those who had seizure and those who were completely seizure free since surgery. Follow-up data were obtained during patients’ regular visits or by phone calls. All patients provided early (within 72 hours of surgery) MRI after surgery and at the 6-month follow-up. Lesionectomy (excision of cavernoma together with the surrounding hemosiderin rim) was our main surgical strategy. If the cavernoma was located in a safe zone (Fig. 1), the surgery would be straightforward: lesionectomy without hesitation. However, in the case of the cavernoma being close to or located in an eloquent area (Fig. 2), awake craniotomy was assisted by cortical electric stimulation, navigation would be performed, and the hemosiderin rim would be removed as much as possible. In the temporal area, we divided the location into two zones: temporal cortical (lateral to the collateral sulcus; Fig. 3) and temporal mesial (medial to the collateral sulcus; Fig. 4). We did not perform the whole mesial temporal resection in the case of medially located small- or medium-sized cavernomas. In the case of a cavernoma located in the temporal neocortex, we did not perform an extended resection, and lesionectomy was again performed. Data from all EEGs were hoped to be consistent with the topographic location of the cavernoma in patients with seizure.

Statistical Analysis

We used a commercially available statistical software package (SPSS version 22.0; IBM Corporation, Inc., Chicago, Illinois, United States) for all statistical analyses. The mean ± standard deviations were calculated for each parameter. Chi-square tests were used for appropriate comparisons. Differences were considered statistically significant if the probability value was less than 0.05.

Results

Table 1 summarizes some clinical and radiological features of the 23 patients. Among the 23 patients, the mean age was 37.08 ± 10.5 years (range: 20–55 years), and 11 (57.8%) and 12 (52.2%) were female and male, respectively. No significant difference was detected in terms of sex (p = 08). Headache (n = 10; 43.5%) and seizure (n = 10; 43.5%) were the most common presenting symptoms. Among the 10 patients with preoperative seizures, generalized tonic-clonic and complex partial seizures were observed in five (50%) and five (50%) patients, respectively. Five (50%) patients had only one seizure, and the remaining five (50%) experienced more than one seizure until surgery. Scalp EEG was performed on only five patients, and it was expected to reveal a unifocal finding with a topographic relation to the cavernoma. Interestingly, only 4 (40%) of the 10 patients with preoperative seizures were on AED when the patients were seen by our team, and all were on monotherapy. Abnormal neurological examinations were found in only two patients (8.7%): one had drowsiness and the other showed motor weakness in both lower extremities.

Table 1

Summary of clinical and radiological characteristics of the patients

No	Age	Sex	Symptom	Finding	Side	Site	Complication	^aF/U
Abbreviations: CSF, cerebrospinal fluid; Cog. Dec., cognitive decline; EDH, epidural hematoma; F, female; M, male. ^aF/U: follow-up (months). ^bNumbness: feeling of numbness on the left hand. ^cWeakness: feeling of weakness on both lower extremities. ^cWeakness: motor weakness on both lower extremities (4/5).
1	20	F	Cog. Dec.	None	Left	Frontal	None	101
2	30	F	Headache	None	Left	Temporal	None	84
3	38	M	Headache	None	Right	Temporal	None	88
4	24	M	Headache	None	Left	Frontal	None	82
5	38	M	Seizure	None	Right	Frontal	None	82
6	49	F	Headache	None	Left	Temporal	None	80
7	51	F	Seizure	None	Left	Frontal	None	76
8	35	F	Headache	Drowsy	Right	Frontal	None	50
9	55	M	Seizure	None	Right	Frontal	EDH	26
10	40	F	^bNumbness	None	Right	Frontal	None	24
11	46	M	Headache	None	Right	Parietal	None	23
12	26	F	Headache	^cWeakness	Right	Temporal	None	20
13	21	F	Seizure	None	Left	Temporal	None	21
14	49	F	Seizure	None	Right	Temporal	None	19
15	36	M	Headache	None	Left	Occipital	CSF fistula	12
16	34	M	Headache	None	Right	Temporal	None	12
17	54	M	Seizure	None	Right	Temporal	None	10
18	32	F	^cWeakness	None	Left	Frontal	None	10
19	36	F	Seizure	None	Left	Frontal	None	36
20	25	M	Headache	None	Right	Occipital	None	23
21	43	M	Seizure	None	Left	Temporal	None	36
22	44	M	Seizure	None	Right	Frontal	None	23
23	27	M	Seizure	None	Right	Temporal	None	12

All patients had MRI with 1.5 or 3T with all sequences. Aside from head MRI, our center also routinely performs digital subtraction angiography to determine the presence or absence of any venous anomaly that may be associated with cavernomas. The head MRI showed that the cavernomas were located on the right side in 13 (56.5%) and on the left side in 10 (43.5%) patients, and that no significant difference was found in terms of location side (p = 0.53). The most common locations were the frontal (n = 10; 43.5%) and temporal (n = 10; 43.5%) lobes, followed by the occipital (n = 2; 8.7%) and parietal (n = 1; 4.3%) lobes. All cavernomas were single and had a hemosiderin rim surrounding them. Among the five temporal cavernomas, two were located medial to the collateral sulcus: one in the uncus and the other in the posterior hippocampal-parahippocampal complex. In five patients (21.7%), the cavernoma was located deeply in the white matter or in deep structures. Two were mesial to the collateral sulcus in the temporal lobe as mentioned above. In the remaining three, one was in the cingulate gyrus, one was in the white matter close to the basal ganglia, and one was in the occipital lobe white matter. All patients had early MRI within 72 hours of surgery, and lesionectomy was shown to be accomplished in all MRI findings.

As the lesionectomy, which is the removal of the cavernoma together with the surrounding hemosiderin rim, we performed in this study has been described in the literature, there is no need to explain it in detail here. We simply emphasize that we did not hesitate to perform lesionectomy in all cavernomas, even those close to the eloquent area. In this series, only three cavernomas located close to the motor strip (two patients) and basal ganglia (one patient) required awake craniotomy with cortical electric stimulation.

After surgery, early neurological examinations revealed that only one patient had left hemiparesis after temporal cavernoma surgery and it was transient. During the long-term follow-up, none of the patients had neurological deficits. Surgery-related complications were observed in two patients (8.7%). One patient had an epidural hematoma following right frontal surgery, and no surgery was required for this complication. The second patient had cerebrospinal fluid fistula, which required surgery, and thus, dural repair was performed. The postoperative course was uneventful, and the patient was discharged from the hospital without further clinical problems.

The mean follow-up in this series was 41.4 ± 30.8 months (range: 10–101 months). During the last follow-up or last visit, all patients were neurologically intact. Among the 10 patients with preoperative seizures, only three patients (30%) had seizures after surgery. Two patients and one patient were operated on the right temporal and left frontal cavernomas, respectively. One had seizure three times since surgery (20-month follow-up), and the other two only had one seizure (one in 3 years and one in the 10-month follow-up). We decided to continue the AED in these three patients, who were closely followed-up by our team to stop the AED in the future. Our results showed that surgery was very effective in seizure outcome, almost 70% of patients who had seizure before surgery was seizure free after surgery, and the difference between those who had seizure pre- and postoperative periods was statistically significant (p = 00001). At the last follow-up, several patients informed us that they sometimes had headaches, which were not severe and did not decrease their quality of life.

Discussion

Common symptoms and/or findings in patients with supratentorial cavernomas include headaches, microhemorrhages, focal neurologic deficits, and epileptic seizures. The current literature5 7 9 10 and our own findings show that epileptic seizures are the most common presenting symptoms. Therefore, it can be accepted now that supratentorial cavernomas with epileptic seizures have become the focus of interest of epileptologists and epilepsy surgeons. Seizures secondary to supratentorial cavernomas should be evaluated in detail in epilepsy patients before surgery, as defining the epileptic zone is of utmost importance given that in almost 6% of patients with supratentorial cavernomas, the focus of seizure is not related to the cavernoma itself.11 The continuation of seizure after the excision of cavernoma may be detrimental to patients and decrease their quality of life. This important issue explains why studies in the current literature have mainly focused on seizure in supratentorial cavernomas.

The exact pathophysiology behind seizures in supratentorial cavernomas has been considered complex and not fully understood. However, an increasing number of studies have indicated that microhemorrhages caused by cavernoma may be responsible for seizures. Microhemorrhages lead to the accumulation of hemosiderin, a degradation product of ferritin, which is the focus of epilepsy.5 7 9 The deposition of hemosiderin and reactive gliosis around a cavernoma may influence the microenvironment where a newly formed synapsis and an increased number of excitatory amino acids may contribute to the development of epilepsy.12 There is a common notion that cavernoma itself has no intrinsic epileptogenic activity, as there is no neuronal tissues within the cavernoma. Furthermore, it has been suggested that a mass effect caused by cavernoma may not explain refractory epilepsy because other large lesions, such as malignant gliomas, are less commonly associated with medically refractory epilepsy.13 Under this premise, it is obvious that the excision of lesions without the surrounding hemosiderin seems insufficient for favorable seizure outcome, and lesionectomy together with the surrounding hemosiderin is probably necessary.

On the basis of the present results, we recommend that hemosiderin should be removed with the cavernoma, and our results on seizure outcome are consistent with the current literature5 6 7 9 10 that a long-term seizure-free rate was found to be 70% in our patients. Only three patients had seizures during the follow-up period, and their seizure frequency significantly decreased. Furthermore, we agree with some studies that hemosiderin rim can be safely removed in cavernomas close to the eloquent area with the assistance of navigation and cortical electric stimulation, given that functional MRI and intraoperative mapping studies have shown that the surrounding hemosiderin is not embedded in the functional cortex.14 In this study, we did not have a chance to evaluate the prognostic factors for seizure outcome mainly because of the low number of patients. However, we can speculate that the location of the lesion did not influence seizure control.

There is still a debate on what should be the limit of excision in patients with seizure secondary to supratentorial cavernoma. Some authors supported extended lesionectomy including the epileptogenic cortex,7 14 but others reported that lesionectomy including the cavernoma and the surrounding hemosiderin is enough to obtain a satisfactory seizure outcome.5 6 9 15 The results of a recent meta-analysis16 showed no significant difference in seizure outcome between extended lesionectomy and lesionectomy, and that the resectioning of the cavernoma and the surrounding hemosiderin is sufficient for patients with a cavernoma with epilepsy. We agree with the majority of studies that lesionectomy is sufficient for a cavernoma with seizure, and extended lesionectomy may lead to a severe neurologic deficit in a cavernoma close to an eloquent area. Our main surgical strategy in supratentorial cavernoma in any location, including deep-seated or white matter-seated, is lesionectomy (excision of the cavernoma with the surrounding hemosiderin), which is safe and effective in terms of seizure outcome and other clinical outcome such as headaches. Another issue we faced during surgery was patients with temporal lobe cavernomas. Previous studies supported the view of extended resectioning, such as the resectioning of the temporal cortex in case of a cavernoma located lateral to the collateral sulcus or the resectioning of the mesial temporal lobe or temporal lobectomy in case of a cavernoma located medial to the collateral sulcus.17 18 We did not perform extended temporal resections in temporal lobe cavernomas in the present series. We think that the two patients with temporal cavernomas who had seizures during the long-term follow-up period deserve to be mentioned here. Both patients had a cavernoma located in the temporal cortex. They suffered only one seizure after surgery, and at the last follow-up, they were seizure free. Seven patients (70%) of the 10 with a temporal cavernoma were completely seizure free since surgery. Thus, unlike in some previous studies, our data did not support the view that extended resectioning of temporal lobe cavernomas is more effective.

Another important point that we want to emphasize is that only four patients among the 10 who had seizures before surgery were on AED when they were seen by our team. We strongly encourage the referred physicians to start AED in patients with a cavernoma with seizure. Our observations indicated that many patients would be seeing several physicians, and the patients were informed that a cavernoma was not a tumor, surgery was not mandatory even with seizure, and AED would not be prescribed. This information could have caused patients to delay admission to advanced surgery clinics, and thus, they continued to have seizures. We emphasize that repetitive seizures may become refractory with time, and that an effective treatment, such as surgery, should be performed as soon as possible to prevent further hemorrhage and refractory seizures.

Study Limitations

The retrospective design, limited number of patients, and relatively short follow-up are the main limitations of the study. Several questions related to surgical techniques can only be answered by performing a prospective study design with a larger patient cohort in the future.

Conclusion

Surgery is safe and effective in supratentorial cavernomas. The excision of a cavernoma together with the surrounding hemosiderin should be performed to obtain a satisfactory seizure outcome. Deep-seated cavernomas or cavernomas close to an eloquent area can be safely removed by conducting awake craniotomy with the assistance of navigation and cortical electric stimulation.

Conflict of Interest

None declared.

Funding None.

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