Phenytoin induced life threatening macroglossia in a child

Rakesh Mondal; Sumantra Sarkar; Tapas Sabui; Partha Pratim Pan

doi:10.4103/0976-3147.105624

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Case Report

4 (

); 75-77

doi:

10.4103/0976-3147.105624

Phenytoin induced life threatening macroglossia in a child

Rakesh Mondal^,, Sumantra Sarkar, Tapas Sabui, Partha Pratim Pan

Departments of Pediatric Medicine, Kolkata, India

1 Department of Pediatric Medicine, IPGME and R and SSKM Hospital, Kolkata, India

2 Departments of Physical Medicine, North Bengal Medical College and Hospital, Darjeeling, India

Dr. Rakesh Mondal Balarampur, Mahestala, Kolkata ‑ 141 India ivanrakesh2001@gmail.com

Journal of Neurosciences in Rural Practice

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Abstract

ABSTRACT

Isolated acquired macroglossia of tongue rarely reported. It occurs due to causes like hereditary angioedema, localized angioedema, etc., Here we describe an 8‑year‑old boy developing life threatening localized angioedema of tongue due to phenytoin without any association with drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome or pseudolymphoma encountered in rural medical college. Anticonvulsants, that is, phenytoin induced this isolated peculiar complication, which was not described before.

Keywords

Angioedema

macroglossia

phenytoin

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Conflicts of interest

None declared

REFERENCES

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Assadi F. K., Wang H. E., Lawless S, Mc Kay C. P., Hopp L, Fattori D, . Angiotensin converting enzyme inhibitor-induced angioedema: a report of two cases. Pediatr Nephrol. 1999;13:917-9.
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[Google Scholar]
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[1] Bork K, Meng G, Staubach P, Hardt J, . Hereditary angioedema: New findings concerning symptoms, affected organs, and course. Am J Med. 2006;119:267-74.
[Google Scholar]

[2] Ji T, Zubkov A. Y., Wijdicks E. F., Manno E. M., Rabinstein A. A., Kotagal S, . Massive tongue swelling in refractory status epilepticus treated with high-dose pentobarbital. Neurocrit Care. 2009;10:73-5.
[Google Scholar]

[3] Kandala V, Playfor S, . Massive tongue swelling following the use of synthetic saliva. Paediatr Anaesth. 2003;13:827-8.
[Google Scholar]

[4] Assadi F. K., Wang H. E., Lawless S, Mc Kay C. P., Hopp L, Fattori D, . Angiotensin converting enzyme inhibitor-induced angioedema: a report of two cases. Pediatr Nephrol. 1999;13:917-9.
[Google Scholar]

[5] Knudsen J. F., Flowers C. M., Kortepeter C, Awaad Y, . Clinical profile of oxcarbazepine-related angioneurotic edema: Case report and review. Pediatr Neurol. 2007;37:134-7.
[Google Scholar]

[6] Alp H, Yavuz H, Alp E, . Melkersson-Rosenthal syndrome: A case report on a child. Kulak Burun Bogaz Ihtis Derg. 2009;19:99-102.
[Google Scholar]

[7] Oelze L. L., Pillow M. T., . Phenytoin-induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Case Report from the Emergency Department. J Emerg Med Aug 16 [Epub ahead of print]
[Google Scholar]

[8] Harris D. W., Ostlere L, Buckley C, Whittaker P, Rustin M. H., . Phenytoin-induced pseudolymphoma. A report of a case and review of the literature. Br J Dermatol. 1992;127:403-6.
[Google Scholar]

[9] Schlaifer D, Arlet P, Montane de la R. P., Ollier S, Abbal M, Le Tallec Y, . Antiepileptic drug-induced lymphoproliferative disorder associated with acquired c1 esterase inhibitor deficiency and angioedema. Eur J Haematol. 1992;48:274-5.
[Google Scholar]

Phenytoin induced life threatening macroglossia in a child

Abstract

ABSTRACT

Keywords

Angioedema

macroglossia

phenytoin

Conflicts of interest

REFERENCES

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