Chordoma of skull base presenting as nasopharyngeal mass

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Abstract

ABSTRACT

While the nasopharynx is most commonly regarded by the otolaryngologist as a primary site of neoplastic involvement, it is also an avenue of spread of base?of?the?skull tumors presenting as bulging nasopharyngeal masses. Chordoma is a relatively rare tumor of the skull base and sacrum thought to originate from embryonic remnants of the notochord. Chordomas arising from the skull base/clivus are typically locally aggressive with lytic bone destruction. The optimal treatment may be photon/proton radiotherapy alone or combined with a gross total resection, when feasible. We report a case of intracranial chordoma presenting as nasopharyngeal mass.

Keywords

Chordoma

nasopharyngeal mass

skull base

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Conflict of Interest

None declared

References

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[1] Nguyen R. P., Salzman K. L., Stambuk H. E., Ahuja A. T., Harnsberger H. R., . Extraosseous Chordoma of the Nasopharynx. AJNR Am J Neuroradiol. 2009;30:803-7.
[Google Scholar]

[2] Mendenhall W. M., Mendenhall C. M., Lewis S. B., Villaret D. B., Mendenhall N. P., . Skull base chordoma. Head Neck. 2005;27:159-65.
[Google Scholar]

[3] Eisemann M. L., . Sphenooccipital chordoma presenting as a nasopharyngeal mass. Ann Otol Rhinol Laryngol. 1980;89:271-5.
[Google Scholar]

[4] Chugh R, Tawbi H, Lucas D. R., Biermann J. S., Schuetze S. M., Baker L. H., . Chordoma: The nonsarcoma primary bone tumor. Oncologist. 2007;12:1344-50.
[Google Scholar]

[5] Mirra J. M., Della Rocca C, Nelson S. D., Mertens F, . Chordoma.Pathology and genetics of tumours of soft tissue and bone. In: editors Lyon, France: IARC Press; 2002. p. p. 316-7.
[Google Scholar]

[6] Yan Z. Y., Yang B. T., Wang Z. C., Xian J. F., Li M, . Primary chordoma in the nasal cavity and nasopharynx: CT and MR imaging findings. AJNR Am J Neuroradiol. 2010;31:246-50.
[Google Scholar]

[7] Cheng T. B., . Nasopharyngeal Chordoma. Singapore Med J. 1963;3:168-70.
[Google Scholar]

[8] Ferraresi V, Nuzzo C, Zoccali C, Marandino F, Vidiri A, Salducca N, et al . Chordoma: Clinical characteristics, management and prognosis of a case series of 25 patients. BMC Cancer. 2010;10:22.
[Google Scholar]

[9] Baratti D, Gronchi A, Pennacchioli E, Lozza L, Colecchia M, Fiore M, et al . Chordoma: Natural history and results in 28 patients treated at a single institution. Ann Surg Oncol. 2003;10:291-6.
[Google Scholar]

[10] Fleming G. F., Heimann P. S., Stephens J. K., Simon M. A., Ferguson M. K., Benjamin R. S., et al . Dedifferentiated chordoma. Cancer. 1993;72:714-8.
[Google Scholar]