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Characteristic Vertebral Imaging in Sickle Cell Disease
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A 32-year-old woman presented with multiple episodes of self-limiting, severe back pain over several years. She was a known patient of sickle cell anemia. Magnetic resonance imaging scans of the dorsal and lumbar spines showed “H-shaped” vertebrae on coronal and sagittal imaging [Figures 1 and 2].


Sickle cell anemia is a condition where red blood cells (RBCs) contain abnormal hemoglobin (Hemoglobin S).[12] When deoxygenated this hemoglobin becomes insoluble and aggregates with similar molecules distorting the shape of the RBCs making them less deformable while they flow through the capillary bed.[1] The abnormally shaped RBCs also have a propensity to adhere to the endothelium.[1] All these lead to vascular occlusion and tissue infarction which manifests clinically as the painful “sickling crisis.”[12]
The microvasculature of the endplates of the vertebrae is a low flow system fed by terminal branches that arise from the arterial grid at the centrum of the vertebrae.[3] Further, the endplates themselves are usually <1 mm thick and are thinnest in the central region.[4] The combination of both these factors leads to endplate infarction with a sharply defined central depression in sickle cell disease as seen in our patient.
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