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Use of triptans for the control of headache in bacterial meningitis
Address for correspondence: Prof. Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok, Thailand. E-mail: wviroj@yahoo.com
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This article was originally published by Medknow Publications & Media Pvt Ltd and was migrated to Scientific Scholar after the change of Publisher.
Sir,
The use of triptans for the control of headache in bacterial meningitis is an interesting topic for discussion.[1] Based on theoretical concern,[2] the feasibility can be seen. Nevertheless, as Mojumder proposed, there are several issues for consideration regarding the effectiveness and safety of triptans. Whether the “thrombogenic environment” has any interrelationship with triptans is an important thing to be further studied. Based on our best knowledge, zolmitriptan and naratriptan have no effect on platelet or coagulation factor. This might assume that using triptans is safe. However, there is a report showing a possibility of increased intrapartum blood loss, which implies anti-thrombogenic phenomenon in the pregnant woman who received triptans.[3] If the anti-thrombogenic property actually exists, it might be a good counter factor to the thrombogenic environment in meningitis. Further studies on this topic are recommended.
References
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