Wernicke’s encephalopathy and central pontine myelinolysis in hyperemesis gravidarum

Panee Sutamnartpong; Sombat Muengtaweepongsa; Kongkiat Kulkantrakorn

doi:10.4103/0976-3147.105608

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Case Report

4 (

); 39-41

doi:

10.4103/0976-3147.105608

Wernicke’s encephalopathy and central pontine myelinolysis in hyperemesis gravidarum

Panee Sutamnartpong, Sombat Muengtaweepongsa, Kongkiat Kulkantrakorn

Department of Neurology, Faculty of Medicine, Thammasart University, Thailand

Address for correspondence: Dr. Panee Sutamnartpong 114/7 Laddarom Village, Ratanathibate Road, Saima, Muang, Nonthaburi Thailand pansutam@yahoo.com

Journal of Neurosciences in Rural Practice

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Abstract

ABSTRACT

A pregnant woman, who had been suffering from hyperemesis gravidarum, presented with alteration of consciousness, ocular nystagmus and ataxia. Magnetic Resonance Imaging of the brain showed typical findings of Wernicke’s encephalopathy and central pontine myelinolysis. The clinical features responded dramatically to thiamine supplementation.

Keywords

Central pontine myelinolysis

hyperemesis gravidarum

Wernicke’s encephalopathy

Show Related Articles from PubMed

Conflicts of interest

None declared

REFERENCES

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[Google Scholar]
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[Google Scholar]
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[Google Scholar]
Thompson P. D., Gledhill R. F., Quinn N. P., Rossor M. N., Stanley P, Coomes E. N., . Neurological complications associated with parenteral treatment: Central pontine myelinolysis and Wernicke’s encephalopathy. Br Med J (Clin Res Ed). 1986;292:684-5.
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Falcone N, Compagnoni A, Meschini C, Perrone C, Nappo A, . Central pontine myelinolysis induced by hypophosphatemia following Wernicke’s encephalopathy. Neurol Sci. 2004;24:407-10.
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[1] Netravathi M, Sinha S, Taly A. B., Bindu P. S., Bharath R. D., . Hyperemesis gravidarum induced Wernicke’s encephalopathy: Serial clinical, electrophysiological and MR imaging observations. J Neurol Sci. 2009;284:214-6.
[Google Scholar]

[2] Sechi G, Serra A, . Wernicke’s encephalopathy: New clinical settings and recent advances in diagnosis and management. Lancet Neurol. 2007;6:442-55.
[Google Scholar]

[3] Martin P. R., Singleton C. K., Hiller-Sturmhofel S, . The role of thiamine deficiency in alcoholic brain disease. Alcohol Res Health. 2003;27:134-42.
[Google Scholar]

[4] Brody T, . Vitamins.Nutritional Biochemistry. (2nd ed). In: San Diego: Academic Press; 1999. p. p. 491-692.
[Google Scholar]

[5] Chiossi G, Neri I, Cavazzuti M, Basso G, Facchinetti F, . Hyperemesis gravidarum complicated by Wernicke encephalopathy: Background, case report, and review of the literature. Obstet Gynecol Surv. 2006;61:255-68.
[Google Scholar]

[6] Galvin R, Brathen G, Ivashynka A, Hillbom M, Tanasescu R, Leone M. A., . EFNS guidelines for diagnosis, therapy and prevention of Wernicke encephalopathy. Eur J Neurol. 2010;17:1408-18.
[Google Scholar]

[7] Zara G, Codemo V, Palmieri A, Schiff S, Cagnin A, Citton V, et al. . Neurological complications in hyperemesis gravidarum. Neurol Sci. 2012;33:133-5.
[Google Scholar]

[8] Bergin P. S., Harvey P, . Wernicke’s encephalopathy and central pontine myelinolysis associated with hyperemesis gravidarum. BMJ. 1992;305:517-8.
[Google Scholar]

[9] Wilson R. K., Kuncl R. W., Corse A. M., . Wernicke’s encephalopathy: Beyond alcoholism. Nat Clin Pract Neurol. 2006;2:54-8. quiz 8
[Google Scholar]

[10] Manzanares W, Hardy G, . Thiamine supplementation in the critically ill. Curr Opin Clin Nutr Metab Care. 2011;14:610-7.
[Google Scholar]

[11] Norenberg M. D., . Central pontine myelinolysis: Historical and mechanistic considerations. Metab Brain Dis. 2010;25:97-106.
[Google Scholar]

[12] Thompson P. D., Gledhill R. F., Quinn N. P., Rossor M. N., Stanley P, Coomes E. N., . Neurological complications associated with parenteral treatment: Central pontine myelinolysis and Wernicke’s encephalopathy. Br Med J (Clin Res Ed). 1986;292:684-5.
[Google Scholar]

[13] Falcone N, Compagnoni A, Meschini C, Perrone C, Nappo A, . Central pontine myelinolysis induced by hypophosphatemia following Wernicke’s encephalopathy. Neurol Sci. 2004;24:407-10.
[Google Scholar]

Wernicke’s encephalopathy and central pontine myelinolysis in hyperemesis gravidarum

Abstract

ABSTRACT

Keywords

Central pontine myelinolysis

hyperemesis gravidarum

Wernicke’s encephalopathy

Conflicts of interest

REFERENCES

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