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Letters to the Editor
3 (
1
); 104-104
doi:
10.4103/0976-3147.91983

Molecular mimicry and cross immunoreactivity in the pathogenesis of Guillain-Barré syndrome

Medical Academic Center, Sukhapibarn, Bangkok, Thailand
Wiwanitkit House, Bangkhae, Bangkok, Thailand
Address for correspondence: Dr. Beuy Joob, Medical Academic Center, Sukhapibarn 1, Bangkok, Thailand. E-mail: beuyjoob@hotmail.com
Licence

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Disclaimer:
This article was originally published by Medknow Publications & Media Pvt Ltd and was migrated to Scientific Scholar after the change of Publisher.

Sir,

In a recent study, Brezovska et al., proposed for “molecular mimicry between the cross-reactive glycoproteins present in C. jejuni and human peripheral nerve and its potential role in the development of GBS following infection with C. jejuni.”[1] This conclusion is still questionable. It is no doubt that the cross immunoreactivity could be seen in the study by Brezovska et al.,[1] and this might be an important part in the pathogenesis of Guillain–Barré syndrome. However, the conclusion on molecular mimicry might not be proper. To conclude a molecular mimicry, there must be the proof for (a) the similarity between structure (secondary and tertiary) structure of the two proteins and (b) the functional similarity between the two proteins. These tests can be performed with help of bioinformatics techniques (structural and functional genomics approach).

Reference

  1. , , , , , , . Immunoreactivity of glycoproteins isolated from human peripheral nerve and Campylobacter jejuni (O:19) J Neurosci Rural Pract. 2011;2:125-9.
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