Fourth ventricular ependymoma with a distant intraventricular metastasis: Report of a rare case

Sudheer Ambekar; Manish Ranjan; Sampath Somanna; Chandrajit Prasad; Vani Santosh

doi:10.4103/0976-3147.116444

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Case Report

4 (

Supp 1

); S121-S124

doi:

10.4103/0976-3147.116444

Fourth ventricular ependymoma with a distant intraventricular metastasis: Report of a rare case

Sudheer Ambekar, Manish Ranjan, Sampath Somanna, Chandrajit Prasad¹, Vani Santosh²

Departments of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India

1Departments of NeuroImaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India

2Departments of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India

Address for correspondence: Dr. Manish Ranjan Department of Neurosurgery, NIMHANS Bangalore - 560 029, Karnataka India drmanishranjan@gmail.com

Journal of Neurosciences in Rural Practice

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Abstract

ABSTRACT

Ependymoma is one of the uncommon tumors of the central nervous system (CNS) in the adult age group. These tumors have a distinct propensity for metastasis, both within and outside the CNS. However, dissemination at the time of first presentation and retrograde dissemination of the tumor is rare. We report the case of a patient with fourth ventricular anaplastic ependymoma who presented with left lateral ventricular metastasis which was anatomically different from the primary tumor. We describe the clinic‑pathological detail of the patient and discuss the probable pathophysiological basis for this rare presentation and its significance in management of the patient.

Keywords

Anaplasia

Cerebrospinal fluid

Ependymoma

Metastasis

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Conflict of Interest

None declared

References

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[Google Scholar]
Shim K. W., Kim D. S., Choi J. U., . The history of ependymoma management. Childs Nerv Syst. 2009;25:1167-83.
[Google Scholar]
Reni M, Brandes A. A., . Current management and prognostic factors for adult ependymoma. Expert Rev Anticancer Ther. 2002;2:537-45.
[Google Scholar]
Verstegen M. J., Leenstra D. T., Ijlst-Keizers H, Bosch D. A., . Proliferation- and apoptosis-related proteins in intracranial ependymomas: An immunohistochemical analysis. J Neurooncol. 2002;56:21-8.
[Google Scholar]
Figarella-Branger D, Lepidi H, Poncet C, Gambarelli D, Bianco N, Rougon G, et al . Differential expression of cell adhesion molecules (CAM), neural CAM and epithelial cadherin in ependymomas and choroid plexus tumors. Acta Neuropathol. 1995;89:248-57.
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Yokoi K, Akiyama M, Yanagisawa T, Takahashi-Fujigasaki J, Yokokawa Y, Mikami-Terao Y, et al . Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma. Childs Nerv Syst. 2007;23:237-42.
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[1] Qian X, Goumnerova L. C., De Girolami U, Cibas E. S., . Cerebrospinal fluid cytology in patients with ependymoma: A bi-institutional retrospective study. Cancer. 2008;114:307-14.
[Google Scholar]

[2] Salazar O. M., . A better understanding of CNS seeding and a brighter outlook for postoperatively irradiated patients with ependymomas. Int J Radiat Oncol Biol Phys. 1983;9:1231-4.
[Google Scholar]

[3] Yuh E. L., Barkovich A. J., Gupta N, . Imaging of ependymomas: MRI and CT. Childs Nerv Syst. 2009;25:1203-13.
[Google Scholar]

[4] Oppenheim J. S., Strauss R. C., Mormino J, Sachdev V. P., Rothman A. S., . Ependymomas of the third ventricle. Neurosurgery.. 1994;34:350-2.
[Google Scholar]

[5] Centeno R. S., Lee A. A., Winter J, Barba D, . Supratentorial ependymomas. Neuroimaging and clinicopathological correlation. J Neurosurg. 1986;64:209-15.
[Google Scholar]

[6] Louis D NOH, Wiestler O. D., Cavenee W. K., . Ependymal tumors.WHO classification of tumors of central nervous system. Lyon Cedex: International Agency for Research on Cancer; 2007. p. :p. 74-80. In: editors
[Google Scholar]

[7] Metellus P, Barrie M, Figarella-Branger D, Chinot O, Giorgi R, Gouvernet J, et al . Multicentric French study on adult intracranial ependymomas: Prognostic factors analysis and therapeutic considerations from a cohort of 152 patients. Brain. 2007;130:1338-49. Pt 5
[Google Scholar]

[8] Wolfsberger S, Fischer I, Hoftberger R, Birner P, Slavc I, Dieckmann K, et al . Ki-67 immunolabeling index is an accurate predictor of outcome in patients with intracranial ependymoma. Am J Surg Pathol. 2004;28:914-20.
[Google Scholar]

[9] Shim K. W., Kim D. S., Choi J. U., . The history of ependymoma management. Childs Nerv Syst. 2009;25:1167-83.
[Google Scholar]

[10] Reni M, Brandes A. A., . Current management and prognostic factors for adult ependymoma. Expert Rev Anticancer Ther. 2002;2:537-45.
[Google Scholar]

[11] Verstegen M. J., Leenstra D. T., Ijlst-Keizers H, Bosch D. A., . Proliferation- and apoptosis-related proteins in intracranial ependymomas: An immunohistochemical analysis. J Neurooncol. 2002;56:21-8.
[Google Scholar]

[12] Figarella-Branger D, Lepidi H, Poncet C, Gambarelli D, Bianco N, Rougon G, et al . Differential expression of cell adhesion molecules (CAM), neural CAM and epithelial cadherin in ependymomas and choroid plexus tumors. Acta Neuropathol. 1995;89:248-57.
[Google Scholar]

[13] Yokoi K, Akiyama M, Yanagisawa T, Takahashi-Fujigasaki J, Yokokawa Y, Mikami-Terao Y, et al . Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma. Childs Nerv Syst. 2007;23:237-42.
[Google Scholar]

[14] Jarvela S, Nordfors K, Jansson M, Haapasalo J, Helen P, Paljarvi L, et al . Decreased expression of antioxidant enzymes is associated with aggressive features in ependymomas. J Neurooncol. 2008;90:283-91.
[Google Scholar]

Fourth ventricular ependymoma with a distant intraventricular metastasis: Report of a rare case

Abstract

ABSTRACT

Keywords

Anaplasia

Cerebrospinal fluid

Ependymoma

Metastasis

Conflict of Interest

References

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