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Commentary
This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article was originally published by Medknow Publications & Media Pvt Ltd and was migrated to Scientific Scholar after the change of Publisher.
Giant cell arteritis (GCA) has a predilection for the extracranial branches of the carotid artery. Classic manifestation of the disease is scalp tenderness and jaw claudication and the temporal artery may appear swollen and pulseless. The disease may affect all organs but the most feared complication is sudden, irreversible blindness. Furthermore, polymyalgia rheumatica is often associated with GCA. The aetiology of both disorders is currently unknown.[12]
GCA is reported to have an uneven geographical distribution.[3] From a Danish perspective it is a relatively common disorder with more than 300 annual inpatient contacts from a background population of five million people [Figure 1].[45] However, GCA is thought to be rare in the developing countries and in patients of Asian background.[3]
- The age-specific rate of Inpatient contacts due to GCA in Denmark in the period 2009-2012. Source
GCA is easy to diagnose and must be suspected in the patients aged over 50 years, with an increased erythrocyte sedimentation rate, and general symptoms of myalgia or headache. The gold-standard for GCA diagnosis is still the temporal artery biopsy, but clinicians need to be aware that false negative results may occur. It is of importance to diagnose GCA since the treatment with glucocorticoids often lead to rapid improvement. The standard treatment regimen is a high-dose glucocorticoid therapy (60 mg/day) which is gradually reduced over several months.[2]
In conclusion, the diagnosis and the treatment of GCA should be common knowledge to all neurologists, and symptoms of this disease must not be misinterpreted as tension type headache or opticneuritis.[67]
References
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