Transient electromyographic findings in serotonergic toxicity due to combination of essitalopram and isoniazid

Çağdas Erdoğan; Eylem Değirmenci; Levent Sinan Bir

doi:10.4103/0976-3147.105616

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Case Report

4 (

); 57-58

doi:

10.4103/0976-3147.105616

Transient electromyographic findings in serotonergic toxicity due to combination of essitalopram and isoniazid

Çağdas Erdoğan^,, Eylem Değirmenci, Levent Sinan Bir

Department of Neurology, Pamukkale University, School of Medicine, Denizli, Turkey

Prof. Çağdas Erdoğan Department of Neurology, Pamukkale University, School of Medicine Denizli Turkey drcagdaserdogan@gmail.com

Journal of Neurosciences in Rural Practice

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Abstract

ABSTRACT

Here, we report a case of serotonergic toxicity due to combination of essitalopram and isoniazid, which was rarely reported before. Moreover, we observed transient neurogenic denervation potentials in needle electromyography, which disappeared with the treatment of serotonergic toxicity. As to our best knowledge, this is the first case, reporting transient electromyographic changes probably due to serotonergic toxicity.

Keywords

Denervation potentials

electromyography

essitalopram

isoniazid

serotonergic toxicity

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Conflicts of interest

None declared

REFERENCES

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[1] Gillman P. K., . Advances pertaining to the pharmacology and interactions of irreversible nonselective monoamine oxidase inhibitors. J Clin Psychopharmacol. 2011;31:66-74.
[Google Scholar]

[2] Polasek T. M., Elliot D. J., Somogyi A. A., Gillam E. M., Lewis B. C., Miners J. O., . An evaluation of potential mechanism-based inactivation of human drug metabolizing cytochromes P450 by monoamine oxidase inhibitors, including isoniazid. Br J Clin Pharmacol. 2006;61:570-84.
[Google Scholar]

[3] Doyle M. E., Hicks D, Aronson N. E., . Selective serotonin reuptake inhibitors and isoniazid: Evidence of a potential adverse interaction. Mil Med. 2001;166:1054-6.
[Google Scholar]

[4] Gillman P. K., . A review of serotonin toxicity data: Implications for the mechanisms ofantidepressant drug action. Biol Psychiatry. 2006;59:1046-51.
[Google Scholar]

[5] Boyer E. W., Shannon M, . The serotonin syndrome. N Engl J Med. 2005;352:1112-20.
[Google Scholar]

[6] Radomki J. W., Dursun S. M., Reveley M. A., Kutcher S. P., . An exploratory approach to the serotonin syndrome: An update of clinical phenomenology and revised diagnostic criteria. Med Hypotheses. 2000;53:218-24.
[Google Scholar]

[7] Nemeroff C. B., Preskorn S. H., Devane C. L., . Antidepressant drug-drug interactions: Clinical relevance and risk management. CNS Spectr. 2007;12:1-13.
[Google Scholar]

[8] Nelson L. S., Erdman A. R., Booze L. L., Cobaugh D. J., Chyka P. A., Woolf A. D., et al. . Selective serotonin reuptake inhibitor poisoning: An evidencebased consensus guideline for out-of-hospital management. Clin Toxicol. 2007;45:315-32.
[Google Scholar]

[9] Huska M. T., Catalano G, Catalano M. C., . Serotonin syndrome associatedwith the use of escitalopram. CNS Spectr. 2007;12:270-4.
[Google Scholar]

[10] Sternbach H, . Serotonin syndrome: How to avoid, identify, and treat dangerous drug interactions. Curr Psych. 2003;5:15-24.
[Google Scholar]

Transient electromyographic findings in serotonergic toxicity due to combination of essitalopram and isoniazid

Abstract

ABSTRACT

Keywords

Denervation potentials

electromyography

essitalopram

isoniazid

serotonergic toxicity

Conflicts of interest

REFERENCES

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