Effect of hyperglycemia on conduction parameters of tibial nerve’s fibers to different muscles: A rat model

Çağdaş Erdoğan; Utku Cenikli; Eylem Değirmenci; Attila Oğuzhanoğlu

doi:10.4103/0976-3147.105602

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Original Article

4 (

); 9-12

doi:

10.4103/0976-3147.105602

Effect of hyperglycemia on conduction parameters of tibial nerve’s fibers to different muscles: A rat model

Çağdaş Erdoğan^,, Utku Cenikli, Eylem Değirmenci, Attila Oğuzhanoğlu

Department of Neurology, Pamukkale University, Denizli, Turkey

Dr. Çaðdaþ Erdoğan Kinikli, Denizli Turkey drcagdaserdogan@gmail.com

Journal of Neurosciences in Rural Practice

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This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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This article was originally published by Thieme Medical and Scientific Publishers Private Ltd. and was migrated to Scientific Scholar after the change of Publisher.

Abstract

ABSTRACT

Introduction: Routine conduction studies reflect the summation of all nerve fibers in a peripheral nerve. Nerve fiber groups to distal, small muscles have smaller diameters than the ones to large proximal muscles. There may be minimal differences between the diameters of nerve fiber groups innervating different muscles; even they are all same type of fibers. So, in neuropathic processes some nerve fiber groups may be more seriously affected. Materials and Methods: 14 rats ( 7 diabetic, 7 control) were studied. Tibial nerve was stimulated from two points and while recorded from a distal (foot intrinsic muscles) and a proximal (gastrocnemius) muscle. Results: There was a significant difference between the proximal and distal recorded conduction velocities. Both proximal and distal recorded conduction velocities decreased during the hyperglycemic process. Discussion: Our method successfully demonstrated different nerve fiber groups; but, the neuropathic process seemed to be homogeneous in both fiber groups.

Keywords

Different nerve fiber groups in the same nerve

hyperglycemia

rat

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Conflicts of interest

None declared

REFERENCES

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[1] Kiziltan M. E., Benbir G, . Clinical and electrophysiological differences in male and female patients with diabetic foot. Diabetes Res Clin Pract. 2008;79:17-8.
[Google Scholar]

[2] Kurt S, Kaplan Y, Karaer H, Erkorkmaz U, . Femoral nerve involvement in diabetics. Eur J Neurol. 2009;16:375-9.
[Google Scholar]

[3] Rodrigues Filho O. A., Fazan V. P., . Streptozotocin induced diabetes as a model of phrenic nerve neuropathy in rats. J Neurosci Methods. 2006;151:131-8.
[Google Scholar]

[4] Weis J, Dimpfel W, Schröder J. M., . Nerve conduction changes and fine structural alterations of extra- and intrafusal muscle and nerve fibers in streptozotocin diabetic rats. Muscle Nerve. 1995;18:175-84.
[Google Scholar]

[5] Henneman E, Olson C. B., . Relatıons between structure and functıon in the desıgn of skeletal muscles. J Neurophysiol. 1965;28:581-98.
[Google Scholar]

[6] Buchthal F, Schmalbruch H, . Motor unit of mammalian muscle. Physiol Rev. 1980;60:90-142.
[Google Scholar]

[7] Mc Hanwell S, Biscoe T. J., . The sizes of motoneurons supplying hindlimb muscles in the mouse. Proc R Soc Lond B Biol Sci. 1981;213:201-16.
[Google Scholar]

[8] Cullheim S, . Relations between cell body size, axon diameter and axon conduction velocity of cat sciatic alpha-motoneurons stained with horseradish peroxidase. Neurosci Lett. 1978;8:17-20.
[Google Scholar]

[9] Oğuzhanoğlu A, Erdoğan C, Tabak E, Cenikli U, . Comparison of conduction velocities of nerve fibers to smaller and larger muscles in rats. Int J Neurosci. 2010;120:76-9.
[Google Scholar]

[10] Gassel M. M., Trojaborg W, . Clinical and electrophysiological study of the pattern of conduction times in the distribution of the sciatic nerve. J Neurol Neurosurg Psychiatry. 1964;27:351-7.
[Google Scholar]

[11] Kawashima R, Kojima H, Nakamura K, Arahata A, Fujita Y, Tokuyama Y, et al. . Alterations in mRNA expression of myelin proteins in the sciatic nerves and brains of streptozotocin-induced diabetic rats. Neurochem Res. 2007;32:1002-10.
[Google Scholar]

[12] Tuncer S, Dalkilic N, Esen H. H., Avunduk M. C., . An early diagnostic tool for diabetic neuropathy: Conduction velocity distribution. Muscle Nerve. 2011;43:237-44.
[Google Scholar]

Effect of hyperglycemia on conduction parameters of tibial nerve’s fibers to different muscles: A rat model

Abstract

ABSTRACT

Keywords

Different nerve fiber groups in the same nerve

hyperglycemia

rat

Conflicts of interest

REFERENCES

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